Organ Donation
Diabetes and Kidney Disease
Organ donation refers to when an individual allows his/her organ(s) to be removed, legitimately, with their consent while they are alive or with the consent of their close relative if the donor is dead. Organs can be donated either by living or deceased donors.
The aim is to raise awareness about the significance of organ donation and to encourage more people towards organ donation in their life.
Donating an organ or tissue is regarded as highly respected, as every organ donation is a gift of life for somebody in need.
One organ donor can save up to 8 lives by donating organs such as one heart, two lungs, one liver, one pancreas, two kidneys, and intestines.
The International Diabetes Federation (IDF) and the World Health Organization (WHO) established World Diabetes Day (WDD) on November 14th in response to rising concerns about the escalating health danger posed by diabetes.
Diabetes is also the most common cause of kidney disease. About 1 out of 3 adults with diabetes have kidney disease. The best way to slow or prevent diabetes-related kidney disease is to control your blood glucose and blood pressure. Healthy living choices and following your doctor’s instructions can help you enhance your overall health.
Here is an infographic that explains more about diabetic kidney disease and the steps you can take to protect your kidneys or delay kidney damage.
Introduction Inflammation plays a central role in determining transplant outcomes. Its intensity varies across living donation, DBD, DCD, and xenotransplantation, with pig xenografts provoking the
Introduction Renal allograft dysfunction, presenting as either acute or gradual loss of kidney function, remains a major complication following transplantation. These conditions often progress silently
Introduction Extracorporeal photopheresis (ECP) is an emerging immunomodulatory therapy that promotes donor-specific tolerance, reduces alloimmunity, and minimizes the need for long-term immunosuppression in transplant patients.
Introduction Interleukin-6 (IL-6) is a key cytokine driving inflammation across multiple organ systems. Sarilumab (SAR), a fully human IL-6 receptor antibody, binds both monomeric and
Introduction The treatment of autoimmune rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and lupus has advanced with the use of disease-modifying anti-rheumatic
Introduction Graft-versus-host disease (GVHD) is a major barrier to the success of hematopoietic stem cell transplantation (HSCT), affecting both survival and quality of life. Macrophages
Introduction Inflammatory arthritis encompasses a range of immune-mediated joint disorders such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA), which lead to chronic joint damage
Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes persistent joint inflammation, leading to pain, stiffness, and eventual cartilage and bone destruction. The
Introduction In the United States, there are currently over 750,000 patients with end-stage renal disease
Introduction Patients who have a kidney transplant frequently experience allograft failure. When a transplant fails,
Introduction The kidney care community has made stunning progress in the past decade developing and disseminating
Introduction The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes the ADA’s
Introduction Precision medicine has already entered clinical practice in kidney transplantation. The individual degree of
Introduction Anemia is a well-known consequence of CKD, It is linked to structural and functional
Introduction This year’s special issue of the Renal Research Institute’s 23rd International Conference on Dialysis,
Introduction Therapeutic treatments for desensitisation and antibody-mediated rejection (AMR) in patients with preformed or de
Introduction (Article introduction authored by Conquest Editorial Team) The field of transplant surgery has been
Introduction There is a considerable imbalance between the demand and supply of donor organs worldwide.
Abstract Recent advances in surgical, immunosuppressive and monitoring protocols have led to the significant improvement
Background Focal segmental glomerulosclerosis (FSGS) is a clinicopathological syndrome characterized by nephrotic-range proteinuria with high
Dr. Shivnarayan .J. Acharya MD, DNB (Nephrology) Consultant Nephrologist Acharya Dialysis Centre & Kidney Hospital,
Abstract The paradigm shift from interferon-based to direct-acting antiviral (DAA) therapy for the treatment of
Background Chronic Kidney Disease (CKD) is a major public health problem and is increasingly being
Abstract Living with chronic kidney disease (CKD) is associated with hardships for patients and their
Introduction Chronic Kidney Disease (CKD) is a deceptive catch all term – almost anything in
Dr. Satish Balan MD, DM, DNB, Senior Consultant Nephrologist, Kerala Institute of Medical Sciences, Thiruvanantapuram,
Dr. Jacob George MBBS, MD, DM (Nephrology), Professor and Head, Department of Nephrology, Medical College
Dr. D Sree Bhushan Raju MD, DM (AIIMS) DNB, FISN, FICP, FIACM, Professor & Head
Introduction After kidney transplantation, rejection and drug-related toxicity occur despite tacrolimus whole-blood pre-dose concentrations ([Tac]blood) being
Introduction Kidney transplantation (KTx) is the preferred treatment for children with stage 5 chronic kidney
Introduction Severe aplastic anemia (SAA) is a serious hematological disease characterized by bone marrow (BM)
Introduction Organ failure is a major cause of illness and death across medical conditions. In
Introduction In patients with cirrhosis, the prevalence of renal dysfunction has been reported to range
Introduction For patients with end-stage renal disease, kidney transplantation (KT) is considered the gold standard
Background There is a paucity of data on the prevalence, adequate timing, and outcome of
Introduction Cadmium exposure is linked to chronic kidney disease (CKD), however the best biomarker for
Introduction Sodium-23 magnetic resonance imaging (23Na MRI) allows the measurement of skin sodium concentration ([Na+]).
Introduction The incidence of end-stage renal disease continues to rise worldwide, and the future demand
Introduction Chronic kidney disease (CKD) is becoming more prevalent as the population ages and increasing
Introduction The intensity and prevalence of rejection in kidney transplant (KT) recipients are influenced by
Introduction Nanomedicine is currently demonstrating considerable potential for new diagnostic and treatment methods for a
Introduction Increasing evidence has suggested that measuring the torque teno virus (TTV) load after immunosuppressive
Introduction Cell-free DNA (cfDNA) is a type of degraded DNA that is released largely by
Introduction Patients with end-stage renal disease (ESRD) who require intermittent hemodialysis (IHD) are more susceptible
Introduction Many kidney disorders are treated with corticosteroids, and immunosuppressive treatment following renal transplantation typically
Introduction According to the latest estimates, more than 320 million patients are treated with dialysis
Introduction Chronic kidney disease progression is linked to a variety of negative outcomes, such as
Introduction Atrial fibrillation (AF) is the most common cardiac arrhythmia and it is frequently encountered
Introduction Gut dysbiosis may be involved in the pathophysiology of CKD and the relationship between
Introduction Only a few therapies have been identified as effective in preventing the advancement of
Introduction For individuals with end-stage organ disease, solid organ transplantation is the gold standard therapy.
Introduction The endothelial glycocalyx is a thin layer consisting of proteoglycans, glycoproteins and glycosaminoglycans that
Introduction The coronavirus disease 2019 (COVID-19) is a respiratory and systemic disease that can infect
Introduction Renal transplantation has become the most effective treatment for end-stage renal illness, although severe
Introduction Cardiovascular disease (CVD) is a leading cause of mortality among chronic renal disease patients
Introduction Kidney transplantation is now the first-line treatment for different forms of end-stage renal failure,
Introduction Urological problems account for the majority of surgical complications in kidney transplant recipients, occurring
Introduction Kidney disease, both acute and chronic, is a major cause of illness and mortality
Introduction End-stage kidney disease (ESKD) is becoming more common around the world. The rising prevalence
Introduction Peritoneal Dialysis (PD) has become more popular in the last decade. Many of these
Introduction As Human Leukocyte Antigen (HLA) antibody detection and measurement tools have improved over the
Introduction Chronic kidney transplant rejection (CKTR) is defined as a gradual loss of renal graft
Background In renal transplant recipients (RTRs), cardiovascular mortality is the most common cause of long-term
Background COVID-19 has been associated with high morbidity and mortality in kidney transplant recipients. However,
Introduction Chronic kidney disease (CKD) is a long-term condition characterized by a progressive and irreversible
Background Lupus nephritis (LN) is one of the most severe complications of SLE patients. We
Purpose Accumulative studies showed that tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) was
Background Most patients with systemic lupus erythematosus (SLE) progress to lupus nephritis (LN) within 5
Introduction Lupus nephritis (LN) is a form of glomerulonephritis that constitutes one of the most
Abstract Although rates of organ donation and solid organ transplantation have been increasing over the
Background An increasing percentage of potential organ donors are infected with hepatitis C virus (HCV).
Background Direct-acting antivirals (DAAs) have revolutionized the treatment of hepatitis C virus (HCV). The impact
Introduction Hepatitis C Virus (HCV) is a common cause of liver failure and cancer that
Background The coronavirus disease 2019 (COVID-19) pandemic poses important challenges to the care of patients
Introduction Chronic kidney disease (CKD) affects 37 million or 15% of the US population and
Introduction The Renal Research Institute’s 22nd International Conference on Dialysis, Advances in Chronic Kidney Disease
Background The prevalence of kidney involvement during SARS-CoV-2 infection has been reported to be high.
Background To aid efforts to manage the coronavirus disease 2019 (COVID-19) pandemic, it is essential
Introduction Inflammation plays a central role in determining transplant outcomes. Its intensity varies across living donation, DBD, DCD, and xenotransplantation, with pig …
Introduction Renal allograft dysfunction, presenting as either acute or gradual loss of kidney function, remains a major complication following transplantation. These conditions …
Introduction Extracorporeal photopheresis (ECP) is an emerging immunomodulatory therapy that promotes donor-specific tolerance, reduces alloimmunity, and minimizes the need for long-term immunosuppression …
Introduction Interleukin-6 (IL-6) is a key cytokine driving inflammation across multiple organ systems. Sarilumab (SAR), a fully human IL-6 receptor antibody, binds …
Introduction The treatment of autoimmune rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and lupus has advanced with the use …
Introduction Graft-versus-host disease (GVHD) is a major barrier to the success of hematopoietic stem cell transplantation (HSCT), affecting both survival and quality …
Introduction Inflammatory arthritis encompasses a range of immune-mediated joint disorders such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA), which lead to …
Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes persistent joint inflammation, leading to pain, stiffness, and eventual cartilage and …
Introduction Kidney transplantation remains the preferred treatment for end-stage kidney disease, offering superior survival and quality of life compared to dialysis. Advances …
Introduction Pure red cell aplasia (PRCA) is a rare but serious complication occurring in 7–10% of patients after major ABO-mismatched allogeneic stem …
Introduction Calcineurin inhibitors (CNIs), particularly tacrolimus, have long been the cornerstone of maintenance immunosuppression following liver transplantation (LT). While effective in preventing …
Introduction Calcineurin inhibitors (CNIs), primarily tacrolimus, are widely used as standard maintenance immunosuppressants in liver transplant (LT) recipients. However, their long-term use …
Introduction Tocilizumab (TCZ), a monoclonal antibody targeting the IL-6 receptor, has become a cornerstone therapy in rheumatoid arthritis (RA) management. It effectively …
The study by Lee et al., published in Clinical and Molecular Hepatology, offers important insights into the long-term risks of chronic kidney …
Introduction Healthcare inequality remains a significant challenge, affecting treatment access and clinical outcomes for various patient groups. In rheumatoid arthritis (RA), disparities …
Introduction High-throughput technologies have revolutionized the understanding of rheumatoid arthritis (RA), revealing new molecular and cellular pathways in tissue inflammation. Fibroblasts, long …
Introduction Kidney transplantation (KT) remains the most common solid organ transplant, with over 25,000 procedures performed annually. Despite the increasing number of …
Introduction Intra-patient variability (IPV) in tacrolimus blood concentrations has emerged as a potential biomarker for managing organ transplant patients. This study explored …
Introduction Diabetes mellitus (DM) in kidney transplant recipients (KTR) significantly increases the risk of mortality, infections, and long-term graft loss. Early identification …
Introduction Kidney transplantation is the best treatment for kidney failure, offering better survival and quality of life than dialysis. However, donor organ …
Introduction Allogeneic hematopoietic cell transplantation (HCT) is a curative treatment for severe aplastic anemia (SAA), but specific transplant guidelines have been lacking. …
Introduction Acquired aplastic anemia (AA) is an immune-mediated bone marrow failure caused by a cytotoxic T-cell attack on hematopoietic stem cells. Diagnosing …
Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation in the joints, leading to pain, stiffness, and progressive disability. …
Introduction Patients with kidney transplants face significant health challenges due to a high burden of pre-existing conditions and the use of immunosuppressive …
Introduction Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting about 1% of the population, mainly women, and significantly increases cardiovascular disease …
Introduction Despite significant advances in the field of transplantation in the past two decades, current clinically available therapeutic options for immunomodulation remain …
Introduction (Article introduction authored by Conquest Editorial Team) Over the past 50 years, aplastic anemia (AA) treatment has transformed from a fatal …
Introduction (Article introduction authored by Conquest Editorial Team) Seropositive rheumatoid arthritis (RA) arises from a complex interplay of genetic and environmental factors, …
Introduction (Article introduction authored by Conquest Editorial Team) A clinical practice guideline (CPG) was developed to provide podiatric recommendations for managing rheumatoid …
Introduction (Article introduction authored by Conquest Editorial Team) Drugs offer therapeutic benefits but can also cause adverse drug reactions (ADRs), ranging from …
Introduction (Article introduction authored by Conquest Editorial Team) Cognitive impairment is common in kidney failure patients, impacting their eligibility for kidney transplant …
Introduction (Article introduction authored by Conquest Editorial Team) A variety of disease-modifying antirheumatic drugs (DMARDs) are now available for treating rheumatoid arthritis …
Introduction (Article introduction authored by Conquest Editorial Team) Acquired aplastic anemia (AA) in children is a rare and life-threatening bone marrow failure …
Introduction (Article introduction authored by Conquest Editorial Team) Rheumatoid arthritis (RA) poses a diagnostic challenge due to its diverse clinical manifestations, ranging …
Introduction (Article introduction authored by Conquest Editorial Team) Advancements in immunosuppression have significantly improved outcomes for kidney transplant recipients (KTR), particularly in …
Introduction (Article introduction authored by Conquest Editorial Team) In kidney transplantation, day-zero biopsies are used to assess organ quality and discriminate between …
Introduction (Article introduction authored by Conquest Editorial Team) Aplastic anemia (AA) is a severe hematopoietic disorder often treated with allogeneic hematopoietic stem …
Introduction (Article introduction authored by Conquest Editorial Team) Chronic graft-versus-host disease (GvHD) treatment response is assessed using NIH Consensus Criteria in clinical …
Introduction (Article introduction authored by Conquest Editorial Team) In recent years, significant strides have been made in understanding the genetic, environmental, and …
Introduction (Article introduction authored by Conquest Editorial Team) The kidney is crucial for filtering waste from the body, with renal transplantation being …
Introduction (Article introduction authored by Conquest Editorial Team) Over the past two decades, treatment options for rheumatoid arthritis (RA) have evolved significantly. …
Introduction (Article introduction authored by Conquest Editorial Team) Kidney transplantation stands as the gold standard for treating end-stage renal diseases (ESRDs), offering …
Introduction (Article introduction authored by Conquest Editorial Team) Balancing immunosuppression in kidney transplant recipients (KTRs) is challenging. Standard triple-drug therapy (tacrolimus, mycophenolate …
Introduction (Article introduction authored by Conquest Editorial Team) Antibody-mediated rejection (AMR) has been- recognized as a prominent contributor to acute and chronic …
Introduction (Article introduction authored by Conquest Editorial Team) The ELITE-Symphony study findings have influenced KDIGO guidelines for renal transplant immunosuppressive therapy. Current …
Introduction (Article introduction authored by Conquest Editorial Team) Graft versus host disease (GVHD) is a serious complication post-allogeneic hematopoietic stem cell transplantation, …
Introduction Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a vital treatment for various benign and malignant diseases, with over 50,000 procedures performed …
Introduction Rheumatoid arthritis (RA) stands as a multifaceted autoimmune disorder marked by persistent inflammation impacting the synovial tissues of numerous joints. Granzymes …
Introduction The TERC gene is vital for maintaining telomeres, and reduced TERC levels can lead to shortened telomeres, which are linked to …
Introduction Chronic anterior uveitis is a concern in up to 20% of children with juvenile idiopathic arthritis (JIA) and can lead to …
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