Introduction (Article introduction authored by Conquest Editorial Team) Acquired aplastic anemia (AA) in children is a rare and life-threatening bone marrow failure disorder, distinct in its diagnosis and treatment from…

Introduction (Article introduction authored by Conquest Editorial Team) Aplastic anemia (AA) is a severe hematopoietic disorder often treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Cytomegalovirus (CMV) reactivation is a…

Introduction (Article introduction authored by Conquest Editorial Team) Chronic graft-versus-host disease (GvHD) treatment response is assessed using NIH Consensus Criteria in clinical trials and clinician assessment in routine practice. Patient-reported…

Introduction (Article introduction authored by Conquest Editorial Team) Graft versus host disease (GVHD) is a serious complication post-allogeneic hematopoietic stem cell transplantation, where donor cells attack the host tissues. It…

Introduction Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a vital treatment for various benign and malignant diseases, with over 50,000 procedures performed globally each year. Pulmonary complications are a significant…

Introduction The TERC gene is vital for maintaining telomeres, and reduced TERC levels can lead to shortened telomeres, which are linked to diseases like aplastic anemia and congenital keratosis. Cell…

Introduction Ocular graft-versus-host-disease (GVHD) remains a significant clinical complication after allogeneic hematopoietic stem cell transplantation. Impaired visual function, pain, and other symptoms severely affect affected individuals’ quality of life. However,…

Introduction Acquired aplastic anemia (AA) is a rare, life-threatening condition in children that results from immune-mediated destruction of stem and progenitor cells in the bone marrow. Standard treatments include allogeneic…

Introduction Graft-versus-host disease (GvHD) is a major problem in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). It is caused by immune reactions associated with donor T-cells toward dissimilar host…

Introduction Aplastic anemia (AA) is an auto-activated T cell-mediated bone marrow failure. Cyclosporine is often used to treat non-severe AA, but the response rate is only 50%. To better predict…