Introduction Acquired aplastic anemia (AA) is an immune-mediated bone marrow failure caused by a cytotoxic T-cell attack on hematopoietic stem cells. Diagnosing AA requires ruling out congenital conditions and myelodysplasia.…
Introduction (Article introduction authored by Conquest Editorial Team) Over the past 50 years, aplastic anemia (AA) treatment has transformed from a fatal diagnosis to one with survival rates exceeding 80–85%.…
Introduction (Article introduction authored by Conquest Editorial Team) Acquired aplastic anemia (AA) in children is a rare and life-threatening bone marrow failure disorder, distinct in its diagnosis and treatment from…
Introduction (Article introduction authored by Conquest Editorial Team) Aplastic anemia (AA) is a severe hematopoietic disorder often treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Cytomegalovirus (CMV) reactivation is a…
Introduction (Article introduction authored by Conquest Editorial Team) Chronic graft-versus-host disease (GvHD) treatment response is assessed using NIH Consensus Criteria in clinical trials and clinician assessment in routine practice. Patient-reported…
Introduction (Article introduction authored by Conquest Editorial Team) Graft versus host disease (GVHD) is a serious complication post-allogeneic hematopoietic stem cell transplantation, where donor cells attack the host tissues. It…
Introduction Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a vital treatment for various benign and malignant diseases, with over 50,000 procedures performed globally each year. Pulmonary complications are a significant…
Introduction The TERC gene is vital for maintaining telomeres, and reduced TERC levels can lead to shortened telomeres, which are linked to diseases like aplastic anemia and congenital keratosis. Cell…
Introduction Ocular graft-versus-host-disease (GVHD) remains a significant clinical complication after allogeneic hematopoietic stem cell transplantation. Impaired visual function, pain, and other symptoms severely affect affected individuals’ quality of life. However,…
Introduction Acquired aplastic anemia (AA) is a rare, life-threatening condition in children that results from immune-mediated destruction of stem and progenitor cells in the bone marrow. Standard treatments include allogeneic…
