Introduction Graft-versus-host disease (GvHD) is a major problem in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). It is caused by immune reactions associated with donor T-cells toward dissimilar host…
Introduction Aplastic anemia (AA) is an auto-activated T cell-mediated bone marrow failure. Cyclosporine is often used to treat non-severe AA, but the response rate is only 50%. To better predict…
Introduction It's not unusual to receive a cancer diagnosis along with a pericardial effusion. The primary cause of pericardial effusion in myeloproliferative diseases and other cancers is the direct invasion…
Introduction Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most successful curative therapy for a wide variety of hematological malignancies, but half of the patients would eventually develop disease relapse.…
Abstract The typical bone marrow failure syndrome, aplastic anaemia (AA), can be either acquired or inherited. While acquired AA is thought to result from a cytotoxic T-cell mediated immunological attack…
Abstract Hematopoietic cell transplantation (HCT) has significantly improved the prognosis for patients with severe aplastic anaemia (SAA); nonetheless, long-term morbidity, in particular the risk of subsequent malignancy, is still a…
Introduction In this context, despite significant progress in the optimization of allogeneic hematopoietic stem cell transplantation (aHSCT), the development of graft-versus-host disease (GVHD) remains a challenge to long-term transplant success…
Introduction Acquired aplastic anemia (AA) is an immune-mediated bone marrow failure syndrome mediated by cytotoxic T lymphocytes targeting patients' own hematopoietic stem cells (HSCs). Although drugs, viral infections, hepatitis, and…
