Introduction (Article introduction authored by Conquest Editorial Team) Despite advances in immunosuppressive treatments-, kidney transplant rejection remains a significant challenge impacting graft longevity. This article provides an overview of the…
Introduction In recent years, advancements in understanding allorecognition and graft rejection mechanisms have revealed a complex immune response involving multiple pathways. Current transplant monitoring relies on traditional markers such as…
Introduction Chronic kidney disease (CKD) affects a significant number of individuals worldwide and is projected to become a leading cause of death in the future. The shortage of kidney donors…
Introduction Kidney transplantation is preferred over hemodialysis for end-stage renal disease (ESRD) patients. While current immunosuppressants inhibit T cell-mediated rejection, antibody-mediated rejection (AMR) caused by donor-specific antibodies against human leukocyte…
Introduction Delayed graft function (DGF) is a common complication of kidney transplantation that can negatively impact short- and long-term outcomes. However, the extent of its adverse impact on transplant outcomes…
Introduction Kidney transplantation improves quality of life, morbidity, and mortality of patients with kidney failure. However, integrated immunosuppressive therapy required to preserve graft function is associated with the development of…
Introduction Organ transplantation remains the ultimate treatment option for terminal organ failure. However, there is a substantial organ shortage because there is a greater demand for organs than there are…
Introduction The most frequent side effects in those who have had kidney transplants (KTx) are urinary tract infections (UTIs). Asymptomatic bacteriuria (ASB) is the most frequent finding in this group…
Introduction Transplant results are less successful when donors and recipients are HLA incompatible. Histocompatibility labs evaluate immunological risk primarily through serologic and cell-based testing. HLA-incompatible transplants have been defined in…
Introduction The number of people receiving kidney transplants who have end-stage renal disease (ESRD) is rising. Long-term allograft survival is generally stable, despite improvements in short-term allograft survival. The optimal…
