Background and Objectives
There exists paucity of data regarding the interaction between post-transplant anemia (PTA) and allograft function in kidney transplantation.
This study aims at investigating the impact of hemoglobin (Hb) on graft failure (non-censored for death) and their interactions.
Study Design
Retrospective analysis of adult kidney transplant recipients between 2000 and 2015 (median follow-up, 7 years) (n=1307)
Key Results
Impact of Hb time on graft failure
Decreased Hb, considering the time-varying effect, was associated with an increased risk of graft failure (HR=1.83; p<0.01).
Graft failure rates
In PTA patients segregated by baseline eslimated glomerular filtration rate (eGFR), the 7-year graft failure rates have been depicted in Figure 1.
Conclusion
The unfavorable impact of PTA was significantly enhanced by low allograft function.
There exists a likelihood of PTA being associated with graft failure due to interaction with allograft function. Therefore, while strategizing treatment modalities, both Hb level and allograft function should be taken into consideration.
