Background and Objectives
Usually, in India, renal failure patients are heavily reliant on live-related or unrelated donors for transplantation. Patients coming from poorer financial circumstances do not go for donor-specific antibody (DSA) detection using Luminex. Such patients, often, experience graft rejection as a consequence of lack of pre-transplant screening and post-transplant care. This article is a compilation of five acute rejection cases comparing their DSA in pre- transplant and post-transplant sera using solid-phase assays.
Methodology
This was a detailed analysis of a consecutive case series as outlined in Table 1.
Key Results
The key findings of the study have been summarized in Table 2.
Conclusions
Patients experiencing acute or hyperacute rejection were found to have DSA with MFI in strong range in their serum.
A greater number of mismatched HLA antigen or difference in the age of donor and recipient can lead to the production of anti-HLA antibodies of higher MFI.
Patients with positive cross-matches undergo screening for the presence of DSA.
